The Great Lakes Odyssey Radio Hour is a public radio series that explores the cultural, environmental, and historical dimensions of the Great Lakes region. The show features stories from across the five lakes - Lake Superior, Michigan, Huron, Erie, and Ontario - highlighting the voices of artists, historians, Indigenous leaders, and community members.

Episodes delve into themes such as water quality, fishing traditions, artistic expression, and Indigenous knowledge, including perspectives from the Anishinabek and the People of the Three Fires. The series is part of a broader multinational initiative inspired by the 50th anniversary of the Great Lakes Water Quality Agreement, aiming to deepen public understanding of the lakes as living systems and cultural touchstones.